The inositol phospholipids

The inositol phospholipids.

T h e dried crystals melted with decomposition a t about 215”. The substance is probably an organic acid but we have not yet had time to examine it thoroughly.” (1) In this modest way inositol seems to have made its first appearance as a lipid constituent. Later in 1930, Anderson and Roberts (2) established the identity of their crystals, obtained from a phospholipid present in avian t...

Inositol phospholipids and cell regulation.

The increased turnover of phosphatidylinositol (PtdIns) in response to activation of cell-surface receptors was discovered by Hokin & Hokin (1953). The structures of the so-called polyphosphoinositides, phosphatidylinositol 4-phosphate (Ptdlns4P) and phosphatidylinositol 4,5-bisphosphate [PtdIns(4,5)P2], were not elucidated until the next decade, but their metabolic importance was suggested by ...

Inositol phospholipids: Translocation, translocation, translocation …

The pleckstrin homology (PH) domains of a number of proteins have been found to interact in vitro with inositol phospholipids; recent experiments show that these interactions may be important in directing protein translocation to specific parts of the cell following stimulus-induced lipid breakdown or synthesis.

No Antistreptomycin Activity Shown by Inositol Phospholipids.

Lipositol, an inositol-containing phospholipid material obtained from soy beans (Woolley: J. Biol. Chem., 147, 581, 1943) was reported to show antistreptomycin activity, with 0.2 ,ug per ml nullifying the antibacterial action of 60 .g per ml of streptomycin (Rhymer et al.: J. Biol. Chem., 169, 457, 1947). Similar materials showing antistreptomycin activity were obtained from brain and plant sou...

The inositol phospholipids: a stereochemical view of biological activity.